Issue 18, 2016

Metal free C–H functionalization of diazines and related heteroarenes with organoboron species and its application in the synthesis of a CDK inhibitor, meriolin 1

Abstract

Here, we report a metal-free cross-coupling reaction of diazines and related heteroarenes with organoboron species via C–H functionalization. The optimized conditions represent a metal-free method for the activation of aryl/heteroarylboronic acids, which undergo coupling with diazines and related heteroarenes. Optimized conditions also find application in the synthesis of a pyrimidine-based potent CDK inhibitor, meriolin1.

Graphical abstract: Metal free C–H functionalization of diazines and related heteroarenes with organoboron species and its application in the synthesis of a CDK inhibitor, meriolin 1

Supplementary files

Article information

Article type
Paper
Submitted
09 Mar 2016
Accepted
05 Apr 2016
First published
18 Apr 2016

Org. Biomol. Chem., 2016,14, 4312-4320

Metal free C–H functionalization of diazines and related heteroarenes with organoboron species and its application in the synthesis of a CDK inhibitor, meriolin 1

T. Thatikonda, U. Singh, S. Ambala, R. A. Vishwakarma and P. P. Singh, Org. Biomol. Chem., 2016, 14, 4312 DOI: 10.1039/C6OB00526H

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