A convenient, versatile, and green CBS-asymmetric reduction of aryl and heteroaryl ketones has been developed by using the microreactor technology. The study demonstrates that it is possible to handle borane solution safely within microreactors and that the reaction performs well using 2-MeTHF as a greener solvent.
S. De Angelis, M. De Renzo, C. Carlucci, L. Degennaro and R. Luisi, Org. Biomol. Chem., 2016, 14, 4304 DOI: 10.1039/C6OB00336B
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