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Issue 18, 2016
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A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems

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Abstract

A convenient, versatile, and green CBS-asymmetric reduction of aryl and heteroaryl ketones has been developed by using the microreactor technology. The study demonstrates that it is possible to handle borane solution safely within microreactors and that the reaction performs well using 2-MeTHF as a greener solvent.

Graphical abstract: A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems

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Article information


Submitted
11 Feb 2016
Accepted
06 Apr 2016
First published
06 Apr 2016

Org. Biomol. Chem., 2016,14, 4304-4311
Article type
Paper

A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems

S. De Angelis, M. De Renzo, C. Carlucci, L. Degennaro and R. Luisi, Org. Biomol. Chem., 2016, 14, 4304
DOI: 10.1039/C6OB00336B

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