An NIR fluorescent/photoacoustic dual-mode probe of NADPH for tumor imaging

Liandi Guan; Wanting Hu; Hongzhi Zuo; Hua Sun; Yongjian Ai; Meng-qi He; Cheng Ma; Mingyu Ding; Qionglin Liang

doi:10.1039/D2CC06354A

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An NIR fluorescent/photoacoustic dual-mode probe of NADPH for tumor imaging†

Liandi Guan,^a Wanting Hu,^a Hongzhi Zuo,^b Hua Sun,

^a Yongjian Ai,^a Meng-qi He,^a Cheng Ma,*^b Mingyu Ding*^a and Qionglin Liang

*^a

Author affiliations

* Corresponding authors

^a MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Laboratory of Flexible Electronics Technology, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, P. R. China
E-mail: dingmy@mail.tsinghua.edu.cn, liangql@tsinghua.edu.cn

^b Department of Electronic Engineering, Tsinghua University, Beijing 100084, China
E-mail: cheng_ma@tsinghua.edu.cn

Abstract

A novel probe was synthesized with a turn-on NIR fluorescent (NIRF)/photoacoustic (PA) response to NADPH, which was successfully applied in both monitoring intracellular NADPH and dual-modal imaging of tumor-bearing mice. It exhibits good potential in studying and understanding the tumor energy metabolism and treatment process related to NADPH.

This article is part of the themed collection: Probing Materials Chemistry

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Article information

DOI: https://doi.org/10.1039/D2CC06354A
Article type: Communication
Submitted: 23 Nov 2022
Accepted: 12 Jan 2023
First published: 12 Jan 2023

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Chem. Commun., 2023,59, 1617-1620

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An NIR fluorescent/photoacoustic dual-mode probe of NADPH for tumor imaging

L. Guan, W. Hu, H. Zuo, H. Sun, Y. Ai, M. He, C. Ma, M. Ding and Q. Liang, Chem. Commun., 2023, 59, 1617 DOI: 10.1039/D2CC06354A

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Chemical Communications

An NIR fluorescent/photoacoustic dual-mode probe of NADPH for tumor imaging†

Abstract

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An NIR fluorescent/photoacoustic dual-mode probe of NADPH for tumor imaging

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