Issue 12, 2023

Circular bivalent aptamers enhance the activation of the regenerative signaling pathway for repairing liver injury in vivo

Abstract

We developed a circular bivalent aptamer (CBA) to precisely activate membrane receptor-mediated regenerative signaling for liver repair in vivo. The CBA showed enhanced biostability and receptor binding avidity, achieving effective pathway activation and satisfactory treatment in an acetaminophen-induced liver injury model. This work expands aptamer-based molecular engineering in regenerative medicine.

Graphical abstract: Circular bivalent aptamers enhance the activation of the regenerative signaling pathway for repairing liver injury in vivo

Supplementary files

Article information

Article type
Communication
Submitted
19 Nov 2022
Accepted
11 Jan 2023
First published
12 Jan 2023

Chem. Commun., 2023,59, 1621-1624

Circular bivalent aptamers enhance the activation of the regenerative signaling pathway for repairing liver injury in vivo

H. Liang, Z. Yan, Y. Tong, S. Chen, J. Li, L. Chen and H. Yang, Chem. Commun., 2023, 59, 1621 DOI: 10.1039/D2CC06176G

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