Issue 41, 2013
From the journal:

Journal of Materials Chemistry B

Water-soluble gold nanoparticles (AuNP) functionalized with a gadolinium(iii) chelate via Michael addition for use as a MRI contrast agent†

Mark Milne,‡a   Pierangelo Gobbo,‡ab   Nevin McVicar,c   Robert Bartha,bc   Mark S. Workentin*ab  and  Robert H. E. Hudson*ab  

* Corresponding authors

a Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada
E-mail: robert.hudson@uwo.ca, mworkent@uwo.ca
Fax: +1-519-661-3022

b Centre for Advanced Materials and Biomaterials, The University of Western Ontario, London, Ontario, Canada

c Robarts Research Institute, Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada

Abstract

A contrast agent suitable for magnetic resonance imaging based on small, water soluble gold nanoparticles (AuNP) conjugated to over 50 Gd3+ chelators has been prepared by using an interfacial Michael addition in aqueous media. The resultant chelator–AuNP conjugates have been successfully characterised by 1H NMR spectroscopy, IR spectroscopy, ICP-OES, ζ-potential analysis, TEM and MRI. T1-weighted in vivo images of mouse kidney were obtained using the agent at 9.4 T. A preliminary in vivo experiment produced no ill effects and the clearance profile of the agent suggests it is suitable for animal testing at clinically relevant concentrations.

Graphical abstract: Water-soluble gold nanoparticles (AuNP) functionalized with a gadolinium(iii) chelate via Michael addition for use as a MRI contrast agent

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Article information

DOI
https://doi.org/10.1039/C3TB20699H
Article type
Paper
Submitted
18 May 2013
Accepted
06 Sep 2013
First published
09 Sep 2013

J. Mater. Chem. B, 2013,1, 5628-5635

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Water-soluble gold nanoparticles (AuNP) functionalized with a gadolinium(III) chelate via Michael addition for use as a MRI contrast agent

M. Milne, P. Gobbo, N. McVicar, R. Bartha, M. S. Workentin and R. H. E. Hudson, J. Mater. Chem. B, 2013, 1, 5628 DOI: 10.1039/C3TB20699H

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