Issue 77, 2012

Triplex-directed covalent cross-linking of a DNA nanostructure

Abstract

The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.

Graphical abstract: Triplex-directed covalent cross-linking of a DNA nanostructure

Supplementary files

Article information

Article type
Communication
Submitted
26 Jul 2012
Accepted
09 Aug 2012
First published
10 Aug 2012

Chem. Commun., 2012,48, 9592-9594

Triplex-directed covalent cross-linking of a DNA nanostructure

D. A. Rusling, I. S. Nandhakumar, T. Brown and K. R. Fox, Chem. Commun., 2012, 48, 9592 DOI: 10.1039/C2CC35407A

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