Issue 37, 2024
From the journal:

Chemical Communications

Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device†

Tong Xu, ORCID logo ‡ab   Zengnan Wu, ORCID logo ‡b   Hongren Yao,b   Yingrui Zhang,ab   Shiyu Chen,ab   Yuxuan Li,b   Xian-Li Meng,a   Yi Zhang*c  and  Jin-Ming Lin ORCID logo *b  

* Corresponding authors

a State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

b Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China
E-mail: jmlin@mail.tsinghua.edu.cn

c Ethnic Medicine Academic Heritage Innovation Research Center, School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China
E-mail: zhangyi@cdutcm.edu.cn

Abstract

A heart-on-a-particle model based on multicompartmental microgel is proposed to simulate the heart microenvironment and study the cardiotoxicity of drugs. The relevant microgel was fabricated by a biocompatible microfluidic-based approach, where heart function-related HL-1 and HUVEC cells were arranged in separate compartments. Finally, the mechanism of aconitine-induced heart toxicity was elucidated using mass spectrometry and molecular biotechnology.

Graphical abstract: Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device

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Article information

DOI
https://doi.org/10.1039/D4CC00396A
Article type
Communication
Submitted
26 Jan 2024
Accepted
27 Mar 2024
First published
28 Mar 2024

Chem. Commun., 2024,60, 4898-4901

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Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device

T. Xu, Z. Wu, H. Yao, Y. Zhang, S. Chen, Y. Li, X. Meng, Y. Zhang and J. Lin, Chem. Commun., 2024, 60, 4898 DOI: 10.1039/D4CC00396A

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