Visible-light-induced nickel-catalysed cross-coupling of 2,2,2-trifluoroethyl pinacol borate with heteroaryl bromides

Abstract

An efficient visible-light-induced nickel-catalysed coupling of 2,2,2-trifluoroethyl pinacol borate with heteroaryl bromides has been reported. A variety of trifluoroethyl heteroarenes were obtained in moderate to good yields. the utility of this reaction was demonstrated by its scale-up via flow chemistry as well as its application to the late-stage modification of some drug-like molecules.