Synthesis of phenolic derivatives via photoredox formal [4 + 2] tandem annulation of α-bromoketones and terminal alkynes

Abstract

A photoredox formal [4 + 2] cycloaddition reaction has been developed, which directly utilizes commercially available and affordable α-bromoketones and terminal alkynes to produce naphthol derivatives in a single step. This method features mild reaction conditions and straightforward operation. The naphthol derivatives obtained can be easily transformed into 4-substituted naphthols, 3-substituted benzofurans, and imidazo heterocycles.