Iridium-catalyzed arylation of sulfoxonium ylides and arylboronic acids: a straightforward preparation of α-aryl ketones

Abstract

A highly efficient iridium(III)-catalyzed arylation coupling of sulfoxonium ylides with arylboronic acids to generate α-aryl ketones has been established for the first time. This protocol proceeded under redox-neutral conditions with a wide substrate scope (56 examples, up to 98% yield), high functional group compatibility, easily accessible starting materials and suitability for late-stage modification of structurally complex drug compounds. Further synthetic applications and elaboration of the product were also accomplished.