Issue 14, 2020

Graphene oxide: a green oxidant-acid bifunctional carbon material for the synthesis of functionalized isoindolin-1-ones via formal amide insertion and substitution

Abstract

A formal amide insertion and substitution reaction for the synthesis of functionalized isoindolin-1-ones was developed on the basis of graphene oxide (GO) as a green and oxidant-acid bifunctional carbon material. A series of N-acylisoindolin-1-ones were synthesized in good to excellent yields directly from benzoisofurans and nitriles in the presence of GO without the need for any additives or metals.

Graphical abstract: Graphene oxide: a green oxidant-acid bifunctional carbon material for the synthesis of functionalized isoindolin-1-ones via formal amide insertion and substitution

Supplementary files

Article information

Article type
Research Article
Submitted
27 Apr 2020
Accepted
12 Jun 2020
First published
15 Jun 2020

Org. Chem. Front., 2020,7, 1796-1801

Graphene oxide: a green oxidant-acid bifunctional carbon material for the synthesis of functionalized isoindolin-1-ones via formal amide insertion and substitution

X. Peng, D. Hu, P. Huang, H. Liao, Y. Zeng, Q. Liu and L. Liu, Org. Chem. Front., 2020, 7, 1796 DOI: 10.1039/D0QO00498G

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