Issue 8, 2024

Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi

Abstract

Covering: up to December 2023

Decalin-containing tetramic acid derivatives, especially 3-decalinoyltetramic acids (3-DTAs), are commonly found as fungal secondary metabolites. Numerous biological activities of this class of compounds, such as antibiotic, antiviral, antifungal, antiplasmodial, and antiprotozoal properties, have been the subject of ongoing research. For this reason, these molecules have attracted a lot of interest from the scientific community and various efforts including semi-synthesis, co-culturing with bacteria and biosynthetic gene sequencing have been made to obtain more derivatives. In this review, 3-DTAs are classified into four major groups based on the absolute configuration of the bicyclic decalin ring. Their biosynthetic pathways, various biological activities, and structure–activity relationship are then introduced.

Graphical abstract: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi

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Article information

Article type
Review Article
Submitted
25 Mar 2024
First published
25 Jun 2024

Nat. Prod. Rep., 2024,41, 1294-1317

Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi

H. W. Kim, J. W. Lee and S. H. Shim, Nat. Prod. Rep., 2024, 41, 1294 DOI: 10.1039/D4NP00013G

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