Issue 8, 2024

Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties

Abstract

The past several years have seen an increase in the discovery and isolation of natural products of the indole alkaloid class. Bis- and tris-indole alkaloids are classes of natural products that have been shown to display diverse, potent biological activities. Of particular interest are bis- and tris-indole alkaloids containing N-heterocyclic linker moieties. It has been reported that more than 85% of biologically active compounds contain one or more heterocyclic moieties; of these, N-heterocycles have been identified as the most prevalent. The goal of this review is to provide a detailed overview of the recent advances in isolation and total synthesis of bis- and tris-indole alkaloids that contain N-heterocyclic linker moieties. The known biological activities of these natural products will also be discussed.

Graphical abstract: Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties

Article information

Article type
Review Article
Submitted
13 Mar 2024
First published
26 Apr 2024
This article is Open Access
Creative Commons BY license

Nat. Prod. Rep., 2024,41, 1264-1293

Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties

K. R. Dvorak and J. J. Tepe, Nat. Prod. Rep., 2024, 41, 1264 DOI: 10.1039/D4NP00012A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements