Co-Catalyzed C(sp3)–C(sp2) bond cleavage via hydrogen atom transfer

Bingqing Zhou; Di Tian; Jinglin An; Yalan Zhou; Rui Yan; Hao Song; Xiao-Yu Liu; Yong Qin

doi:10.1039/D2QO00125J

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Co-Catalyzed C(sp³)–C(sp²) bond cleavage via hydrogen atom transfer†

Bingqing Zhou,‡^a Di Tian,‡^a Jinglin An,^a Yalan Zhou,^a Rui Yan,^a Hao Song,^a Xiao-Yu Liu

*^a and Yong Qin

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan Province, China
E-mail: xyliu@scu.edu.cn, yongqin@scu.edu.cn

Abstract

The discovery of a new Co-catalyzed hydrogen atom transfer (HAT) C(sp³)–C(sp²) bond cleavage method to access ketones from alkenes is reported. This unprecedented transformation features mild reaction conditions and good functional group compatibility, and it proceeds through a key alkoxy radical formation and subsequent β-fragmentation approach.

This article is part of the themed collection: 2022 Organic Chemistry Frontiers HOT articles

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Article information

DOI: https://doi.org/10.1039/D2QO00125J
Article type: Research Article
Submitted: 24 Jan 2022
Accepted: 05 Mar 2022
First published: 08 Mar 2022

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Org. Chem. Front., 2022,9, 2135-2140

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Co-Catalyzed C(sp³)–C(sp²) bond cleavage via hydrogen atom transfer

B. Zhou, D. Tian, J. An, Y. Zhou, R. Yan, H. Song, X. Liu and Y. Qin, Org. Chem. Front., 2022, 9, 2135 DOI: 10.1039/D2QO00125J

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