Synthesis of new nucleosides containing a fused cyclopropane ring 1-{(1R,3R,5R)-2-oxabicyclo[3.1.0]hexan-3-yl}-thymine and -uracil
Abstract
1-{(1R,3R,5R)-2-Oxabicyclo[3.1.0]hexan-3-yl}-thymine and -uracil have been obtained by the cathodic reduction of 3′,5′-dideoxy-3′,5′-di-iodothymidine and 2′,3′,5′-trideoxy-3′,5′-di-iodouridine, respectively.