Cephalosporanic acid derivatives (I) were converted into 3-methylenecepham derivatives (II) on treatment with chromium(II) salts in aqueous media, and esters of 3-methylenecepham derivatives were readily isomerized to the 3-methyl-3-cephem derivatives (VII) under basic conditions.
M. Ochiai, O. Aki, A. Morimoto, T. Okada and H. Shimadzu, J. Chem. Soc., Chem. Commun., 1972, 800 DOI: 10.1039/C39720000800
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