Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 27, 2018

A multifunctional SERS sticky note for real-time quorum sensing tracing and inactivation of bacterial biofilms

Author affiliations

Abstract

Quorum sensing (QS) is crucial for bacterial survival and activity. Although detecting related signaling metabolites can reveal QS, a versatile platform for convenient real-time imaging of their secretion in the context of bacterial biofilms along with inhibition to the growth of biofilms is still highly desired. Here we develop a flexible sticky note with a sandwich structure by encapsulating gold nanostars between two pieces of hexagonal boron nitride layers, which can be easily pasted on natural biofilms to monitor in real-time the secreted signaling molecule by SERS imaging with high sensitivity and spatiotemporal resolution. Using Pseudomonas aeruginosa and its pyocyanin secretion as a model and an internal standard for self-calibration of SERS signals, the sticky note achieves reliable quantification and a rapid response to the secretion as early as 1 h biofilm growth. With antibiotic loading, the multifunctional SERS sticky note also demonstrated effective inactivation of the bacterial biofilm with simultaneous evaluation of the inactivation effect. This multifunctional SERS sticky note provides a versatile platform for investigating bacterial behaviors and developing antibacterial therapeutics.

Graphical abstract: A multifunctional SERS sticky note for real-time quorum sensing tracing and inactivation of bacterial biofilms

Supplementary files

Article information


Submitted
09 May 2018
Accepted
30 May 2018
First published
31 May 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 5906-5911
Article type
Edge Article

A multifunctional SERS sticky note for real-time quorum sensing tracing and inactivation of bacterial biofilms

J. Guo, Y. Liu, Y. Chen, J. Li and H. Ju, Chem. Sci., 2018, 9, 5906 DOI: 10.1039/C8SC02078G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements