Issue 71, 2014
From the journal:

RSC Advances

Synthesis and bioactivity of nobilamide B†

M. P. V. Jacinto,a   M. S. Flores,b   Z. Lin,c   G. P. Concepcion,b   E. W. Schmidt,c   S. Faulknerd  and  A. J. L. Villaraza*a  

* Corresponding authors

a Institute of Chemistry, College of Science, National Science Complex, University of the Philippines, Diliman, Quezon City, Philippines
E-mail: alvillaraza@up.edu.ph

b Marine Science Institute, College of Science, National Science Complex, University of the Philippines, Diliman, Quezon City, Philippines

c Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah UT 84112, USA

d Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK

Abstract

An alternative and facile solution/solid-phase approach is reported for the total synthesis of neuroactive peptide, nobilamide B. Z-Dhb was formed in solution via EDC/CuCl induced elimination. The solid-phase synthesis employed HBTU/Oxyma Pure™ coupling using Barlos resin. Synthetic nobilamide B was also found to be neuroactive in primary cultures of dorsal root ganglion (DRG) neurons.

Graphical abstract: Synthesis and bioactivity of nobilamide B

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Article information

DOI
https://doi.org/10.1039/C4RA06873D
Article type
Communication
Submitted
09 Jul 2014
Accepted
12 Aug 2014
First published
18 Aug 2014

RSC Adv., 2014,4, 37609-37612

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Synthesis and bioactivity of nobilamide B

M. P. V. Jacinto, M. S. Flores, Z. Lin, G. P. Concepcion, E. W. Schmidt, S. Faulkner and A. J. L. Villaraza, RSC Adv., 2014, 4, 37609 DOI: 10.1039/C4RA06873D

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