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Issue 72, 2018
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Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

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Abstract

A novel strategy for the production of reactive [18F]fluoride has been developed, omitting time consuming azeotropic drying procedures. Gaseous [18F]triflyl fluoride is formed instantaneously at room temperature from hydrated [18F]fluoride, followed by distillation in less than 5 minutes into a dry aprotic solvent, in which dry [18F]fluoride is released in presence of base with >90% radiochemical yield. The reactivity of the [18F]fluoride has been confirmed by reaction with several model compounds and by the synthesis of the PET tracers [18F]fluoroestradiol ([18F]FES) and O-2-[18F]fluoroethyl-L-tyrosine ([18F]FET), providing good isolated radiochemical yields and molar activities of up to 123 GBq μmol−1.

Graphical abstract: Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

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Article information


Submitted
20 Apr 2018
Accepted
01 Jun 2018
First published
23 Aug 2018

This article is Open Access

Chem. Commun., 2018,54, 10179-10182
Article type
Communication

Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

A. Pees, C. Sewing, M. J. W. D. Vosjan, V. Tadino, J. D. M. Herscheid, A. D. Windhorst and D. J. Vugts, Chem. Commun., 2018, 54, 10179
DOI: 10.1039/C8CC03206H

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