Mechanochemical synthesis of bis-benzoquinonylmethanes promoted by sulfonic acid-functionalized chitosan
Iva Souza
de Jesus, 
*ab
Fernando
de Carvalho da Silva
b
and
*ab
Fernando
de Carvalho da Silva
b
and
Abstract
A sustainable mechanochemical method for synthesizing functionalized bis-lawsones from 2-hydroxynaphthalene-1,4-dione and aldehydes under solvent-free conditions is described. Sulfonated chitosan acts as both a biodegradable grinding auxiliary and a solid acid promoter, enabling high yields, broad tolerance to aryl-substituted aldehydes, and recyclability over multiple cycles with minimal loss of activity. The protocol is readily scalable without compromising efficiency.
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