Acid-responsive metal organic frameworks with photothermal effects for osteoarthritis multiple therapy

Abstract

Early osteoarthritis (OA) with reversible ability appears to lack features other than intense acute inflammation. Herein, we developed a pH-responsive metal organic framework (MOF) system based on phenylboronic acid (PBA) and O-hydroxyl pH-dependent reversible switches. Click chemistry enables a simple and environmentally friendly synthesis process and sensitive drug release procedure. Nanoparticles possess excellent photothermal conversion capabilities that enable thermal interventions alongside sustained drug release, thereby treating early OA in multiple ways. The results indicate that nanoparticles have high drug-loading capacity and can respond to the weakly acidic conditions in the OA microenvironment to release ellagic acid (EA) gradually. It can also significantly reduce inflammatory reactions induced by IL-1β. The high effectiveness of this compound therapy is comprehensively demonstrated by both in vitro and vivo evidence.