Plasmonic nanopore to monitor in-pore chemistry

Abstract

Reliable control of solid-state nanopore gating remains challenging. Voltage-controlled metal phosphate reactions enable reversible pore blocking via cyclic precipitation and dissolution driven by cation transport. Negative bias blocks ion flow, while polarity reversal restores conductance, forming a nanofluidic diode. Here we show how plasmonic nanopores allow in-pore SERS measurements, directly confirming the localized chemistry and enabling high-resolution monitoring of nanoscale processes