A modification-free nanochannel platform for monitoring cerebral β-amyloid peptides based on the dispersion of stimuli-responsive polymer-modified gold nanoparticles

Abstract

We developed a modification-free glass nanochannel for sensitive and selective detection of Aβ monomers, which operates through a dispersion-dominated recognition mechanism based on stimuli-responsive polymer-functionalized gold nanoparticles. This platform was successfully applied to monitor Aβ monomers in live mouse brains in Alzheimer's disease combined with in vivo midrodialysis.