A ruthenium(p-cymene)–cupin complex functioning as an artificial ketone reductase was developed through structure-guided engineering. Refinement of the primary and secondary coordination spheres based on a 1-His metal-binding motif enabled efficient asymmetric transfer hydrogenation of trifluoroacetophenone in water, affording up to 95% ee and 92% coupling efficiency.
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K. Matsumoto, S. Kitazawa, R. Matsumoto, Y. Morita and N. Fujieda, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC07188G
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