Catalytic efficiency of Cu-MOFs: HKUST-1 and CuBDC for the protodeboronation of aryl boronic acids

Abstract

This study investigates the catalytic potential of copper-based metal–organic frameworks (Cu-MOFs), specifically HKUST-1 and CuBDC, for the protodeboronation of aryl boronic acids. Protodeboronation, was explored under various bases, atmospheres, and substrates. Optimal conditions using K₂CO₃ as the base and an oxygen atmosphere yielded up to 98% product with HKUST-1. While CuBDC also exhibited catalytic activity, its yields were slightly lower under identical conditions. Substrate size and substituent effects played a crucial role, with bulkier substrates favoring higher yields. Recyclability tests confirmed that both Cu-MOFs retained catalytic activity over three cycles, despite some structural changes. These findings demonstrate Cu-MOFs as promising heterogeneous catalysts for controlled protodeboronation.