From the journal:

Organic & Biomolecular Chemistry

Electrophilic fluorination of cannabinol (CBN)†

Urvashi, ORCID logo a   Melvin Druelinger, ORCID logo *a   John Hatfielda  and  Kenneth J. Olejar*a  

* Corresponding authors

a Chemistry Department, Colorado State University – Pueblo, Pueblo, Colorado 81001, USA
E-mail: mel.druelinger@csupueblo.edu, kenneth.olejar@csupueblo.edu

Abstract

Several fluorinated cannabinol compounds (3a–g) were synthesised via an electrophilic fluorination process. This resulted in the formation of two mono-fluorinated aromatic ring products, a difluorinated aromatic ring product and four new oxidized poly-fluorinated cyclohexadienones. Two of these are difluorinated isomers and two are trifluorinated isomers.

Graphical abstract: Electrophilic fluorination of cannabinol (CBN)

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Article information

DOI
https://doi.org/10.1039/D5OB00378D
Article type
Communication
Submitted
02 Mar 2025
Accepted
10 Apr 2025
First published
24 Apr 2025

Org. Biomol. Chem., 2025, Advance Article

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Electrophilic fluorination of cannabinol (CBN)

Urvashi, M. Druelinger, J. Hatfield and K. J. Olejar, Org. Biomol. Chem., 2025, Advance Article , DOI: 10.1039/D5OB00378D

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