TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3H)-ones from 2-aminobenzamides and isothiocyanates

Abstract

A practical protocol has been established to access 2-aminoquinazolin-4(3H)-one derivatives through the electrochemical desulfurative cyclization of 2-aminobenzamides and isothiocyanates. The protocol allows for the formation of C–N bonds under mild conditions without metal catalysts or external oxidants. The practicability of this strategy is demonstrated by its broad substrate scope, good functional group compatibility, and scale-up synthesis.