Cobalt-catalyzed regio- and stereoselective synthesis of atropisomers with vicinal C–C and C–N diaxes

Abstract

A regio-, diastereo-, and enantioselective cobalt-catalyzed C–H activation/annulation of aromatic and alkenyl amides has been developed to access heterocycles featuring vicinal C–C and C–N diaxes. This strategy uniquely harnesses previously unexplored electronically unbiased internal alkynes and proceeds under mild conditions to deliver products in high yields with excellent regio- and stereocontrol.