Dynamic membranization results in core–shell coacervates that selectively localize particles and small molecules

Tsvetomir Ivanov; Shoupeng Cao; Maximilian Schaaf; Lucas Caire da Silva; Katharina Landfester

doi:10.1039/D5CC02423D

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Dynamic membranization results in core–shell coacervates that selectively localize particles and small molecules

Tsvetomir Ivanov,

^a Shoupeng Cao,

^ab Maximilian Schaaf,

^a Lucas Caire da Silva

*^ac and Katharina Landfester

*^a

Author affiliations

* Corresponding authors

^a Department Physical Chemistry of Polymers, Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany
E-mail: landfester@mpip-mainz.mpg.de

^b College of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, P. R. China

^c Department of Chemistry, McGill University, Montreal, Canada
E-mail: lucas.cairedasilva@mcgill.ca

Abstract

We present a dynamic multiphase coacervate system that enables selective molecular partitioning, mimicking cellular compartmentalization. This pH-responsive platform separates enzymatic products based on polarity and exhibits enhanced colloidal stability for prolonged use. These advances position multiphase coacervates as robust tools for catalysis, synthetic biology, and bio-inspired chemical systems.

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DOI: https://doi.org/10.1039/D5CC02423D
Article type: Communication
Submitted: 23 May 2025
Accepted: 26 Aug 2025
First published: 29 Aug 2025
This article is Open Access

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Chem. Commun., 2025,61, 15227-15230

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Dynamic membranization results in core–shell coacervates that selectively localize particles and small molecules

T. Ivanov, S. Cao, M. Schaaf, L. Caire da Silva and K. Landfester, Chem. Commun., 2025, 61, 15227 DOI: 10.1039/D5CC02423D

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Chemical Communications

Dynamic membranization results in core–shell coacervates that selectively localize particles and small molecules

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Dynamic membranization results in core–shell coacervates that selectively localize particles and small molecules

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