Anthony Choi, Anjan Das, Anthony J. H. M. Meijer, Ilaria Proietti Silvestri and Iain Coldham
Org. Biomol. Chem., 2024,22, 1602-1607
DOI:
10.1039/D4OB00011K,
Communication
Open Access Learn more..Kinetic resolution of N-Boc-spirocyclic 2-arylpiperidines with spiro substitution at C-4 was achieved with high enantiomeric ratios using the chiral base n-BuLi/sparteine. Cyclopropanation or metallaphotoredox catalysis were used to access the piperidines, which could be further functionalised without loss of enantiopurity, highlighting their use as potential 3D fragments for drug discovery.
