Recent advances in oxidative chlorination

Abstract

Considering the wide occurrence and extensive application of organic chlorides in many research fields, the development of easy, practical and green chlorination methodologies is much needed. In the oxidative chlorination strategy, active chlorinating species can be in situ formed by the interaction of easily accessible chlorides such as NaCl, HCl, KCl, CHCl₃, etc. and suitable oxidants. Among the established chlorination approaches, this strategy is an attractive one as it features the use of readily available, cheap and safe inorganic or organic chlorides, good atom economy of chlorine, and multiple choices of oxidants. This review summarizes the representative methodologies in the field of oxidative chlorination, covering 2013 to 2023.