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Abstract | Cited by

In this study, we report amino acid amidation using hexylsilane and a catalytic amount of 1,2,4-triazole. The conventional protection/deprotection method for the α-amino group of amino acids is not required. The corresponding α-amino amides were obtained in moderate to good yields with low to no racemization.

Graphical abstract: Hexylsilane-mediated direct amidation of amino acids with a catalytic amount of 1,2,4-triazole

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