Metal-free synthesis of 1,3-dichloro-1,5-diarylpentan-5-ones via cascade oxidative radical addition of styrenes with CHCl3

Min Liu; Bifu Liu; Qian Wang; Kejun Feng; Yuanhua Li; Lixin Liu; Jiaen Tong

doi:10.1039/D3OB01403G

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Metal-free synthesis of 1,3-dichloro-1,5-diarylpentan-5-ones via cascade oxidative radical addition of styrenes with CHCl₃†

Min Liu,

^ab Bifu Liu,

*^ab Qian Wang,^a Kejun Feng,^a Yuanhua Li,

^a Lixin Liu

^a and Jiaen Tong^a

Author affiliations

* Corresponding authors

^a School of Chemistry and Materials Engineering, Huizhou University, Huizhou 516007, China
E-mail: liubf@hzu.edu.cn

^b Guangdong Provincial Key Laboratory of Electronic Functional Materials and Devices, Huizhou University, Huizhou 516001, Guangdong, P. R. China

Abstract

A novel and efficient metal-free cascade oxidative radical addition of styrenes is developed for the construction of 1,3-dichloro-1,5-diarylpentan-5-ones. This protocol presents a practical one-pot procedure that delivers highly functionalized 1,3-dichloro-1,5-diarylpentan-5-ones in moderate-to-good yields with a broad substrate scope under mild conditions.

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Supplementary files

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Article information

DOI: https://doi.org/10.1039/D3OB01403G
Article type: Communication
Submitted: 02 Sep 2023
Accepted: 14 Nov 2023
First published: 14 Nov 2023

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Org. Biomol. Chem., 2024,22, 699-702

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Metal-free synthesis of 1,3-dichloro-1,5-diarylpentan-5-ones via cascade oxidative radical addition of styrenes with CHCl₃

M. Liu, B. Liu, Q. Wang, K. Feng, Y. Li, L. Liu and J. Tong, Org. Biomol. Chem., 2024, 22, 699 DOI: 10.1039/D3OB01403G

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Organic & Biomolecular Chemistry