Correlative multimodal optical and X-ray fluorescence imaging of brominated fluorophores

Abstract

Imaging with multiple modalities can maximise the information gained from the analysis of a single sample. probes for optical fluorescence and X-ray fluorescence microscopy based on brominated 4-amino-1,8-naphthalimide and BODIPY scaffolds have been successfully designed and synthesised. Herein we show that these prototype probes, based on each of these scaffolds, can be imaged in two different cancer cell lines, and that the respective optical fluorescence and X-ray fluorescence signals are well correlated in these images.

Graphical abstract: Correlative multimodal optical and X-ray fluorescence imaging of brominated fluorophores

Supplementary files

Article information

Article type
Communication
Submitted
26 Apr 2024
Accepted
13 Jun 2024
First published
20 Jun 2024

Chem. Commun., 2024, Advance Article

Correlative multimodal optical and X-ray fluorescence imaging of brominated fluorophores

L. D. Adair, M. E. Graziotto, T. Koh, C. J. Kidman, B. J. Schwehr, M. J. Hackett, M. Massi, H. H. Harris and E. J. New, Chem. Commun., 2024, Advance Article , DOI: 10.1039/D4CC01956C

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