Issue 32, 2023

Highly active nanoparticle enhanced rapid adsorption-killing mechanism to combat multidrug-resistant bacteria

Abstract

Contact-killing surfaces with the ability to rapidly adsorb and kill microorganisms are desperately needed since the rapid outbreak of multidrug-resistant (MDR) bacteria poses a serious threat to human health. Therefore, a series of amphiphilic nanoengineered polyquaterniums (ANPQs) were synthesized, and immobilizing ANPQs onto equipment surfaces provided a simple method for preventing microbial infections. The strong charge-positive property of ANPQ offered the possibility of rapid adsorption and efficient killing, such that all bacteria are adsorbed after 10 seconds of contact with ANPQ-treated fabrics, and more than 99.99% of pathogens are killed within 30 seconds. Surprisingly, the adsorption-killing mechanism made it difficult for bacteria to develop resistance to ANPQ coating, even after long-term repeated treatment. Importantly, in a Methicillin-resistant Staphylococcus aureus infection model, ANPQ-treated fabrics exhibited a potent anti-infectious performance while remaining nontoxic. It is envisaged that the strategy of using ANPQ coating undoubtedly provides a promising candidate for fighting MDR strains.

Graphical abstract: Highly active nanoparticle enhanced rapid adsorption-killing mechanism to combat multidrug-resistant bacteria

Supplementary files

Article information

Article type
Paper
Submitted
15 May 2023
Accepted
31 May 2023
First published
21 Jul 2023

J. Mater. Chem. B, 2023,11, 7750-7765

Highly active nanoparticle enhanced rapid adsorption-killing mechanism to combat multidrug-resistant bacteria

Y. Xue, Z. Zhao, W. Huang, Z. Qiu, X. Li, Y. Zhao, C. Wang, R. Cui, S. Shen, H. Tian, L. Fang, R. Zhou and B. Zhu, J. Mater. Chem. B, 2023, 11, 7750 DOI: 10.1039/D3TB01105D

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