Issue 89, 2023

Detection and tracking of cytoplasmic G-quadruplexes in live cells

Abstract

A TTPP probe was developed to distinguish G-quadruplexes (G4s) from other nucleic acid topologies through longer fluorescence lifetimes and higher quantum yields. In fluorescence lifetime imaging microscopy, TTPP enabled the visualization of cytoplasmic G4s in live cells, and showed the potential to detect cell apoptosis and ferroptosis by tracking cytoplasmic G4s.

Graphical abstract: Detection and tracking of cytoplasmic G-quadruplexes in live cells

Supplementary files

Article information

Article type
Communication
Submitted
24 Jun 2023
Accepted
21 Sep 2023
First published
16 Oct 2023

Chem. Commun., 2023,59, 13348-13351

Detection and tracking of cytoplasmic G-quadruplexes in live cells

L. Rao, L. Hao, L. Liu, Y. Zeng, B. Liang, W. Liu and Z. Mao, Chem. Commun., 2023, 59, 13348 DOI: 10.1039/D3CC03043A

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