Issue 78, 2023

Development of DACN-NHS-ester and DACN-maleimide, and their application for the synthesis of artificial hybrid biomolecules

Abstract

DACN-NHS-ester and DACN-maleimide were developed as molecular connectors and applied for the synthesis of artificial hybrid biomolecules in two steps, including, step 1: connection to a corresponding molecule via the NHS ester or maleimide unit, followed by step 2: connection to a corresponding azido-containing molecule via DACN unit by copper-free-alkyne-azide-cycloaddition.

Graphical abstract: Development of DACN-NHS-ester and DACN-maleimide, and their application for the synthesis of artificial hybrid biomolecules

Supplementary files

Article information

Article type
Communication
Submitted
23 Jun 2023
Accepted
14 Aug 2023
First published
13 Sep 2023

Chem. Commun., 2023,59, 11724-11727

Development of DACN-NHS-ester and DACN-maleimide, and their application for the synthesis of artificial hybrid biomolecules

Y. Kawasaki, T. Hayashibara, Y. Seto, Y. Taniguchi, K. Igawa and K. Tomooka, Chem. Commun., 2023, 59, 11724 DOI: 10.1039/D3CC03023G

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