Issue 62, 2023

Combined homogeneous and heterogeneous hydrogenation to yield catalyst-free solutions of parahydrogen-hyperpolarized [1-13C]succinate

Abstract

We show that catalyst-free aqueous solutions of hyperpolarized [1-13C]succinate can be produced using parahydrogen-induced polarization (PHIP) and a combination of homogeneous and heterogeneous catalytic hydrogenation reactions. We generate hyperpolarized [1-13C]fumarate via PHIP using para-enriched hydrogen gas with a homogeneous ruthenium catalyst, and subsequently remove the toxic catalyst and reaction side products via a purification procedure. Following this, we perform a second hydrogenation reaction using normal hydrogen gas to convert the fumarate into succinate using a solid Pd/Al2O3 catalyst. This inexpensive polarization protocol has a turnover time of a few minutes, and represents a major advance for in vivo applications of [1-13C]succinate as a hyperpolarized contrast agent.

Graphical abstract: Combined homogeneous and heterogeneous hydrogenation to yield catalyst-free solutions of parahydrogen-hyperpolarized [1-13C]succinate

Supplementary files

Article information

Article type
Communication
Submitted
13 Apr 2023
Accepted
20 Jun 2023
First published
14 Jul 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 9509-9512

Combined homogeneous and heterogeneous hydrogenation to yield catalyst-free solutions of parahydrogen-hyperpolarized [1-13C]succinate

J. Eills, R. Picazo-Frutos, D. B. Burueva, L. M. Kovtunova, M. Azagra, I. Marco-Rius, D. Budker and I. V. Koptyug, Chem. Commun., 2023, 59, 9509 DOI: 10.1039/D3CC01803B

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