Issue 45, 2023
From the journal:

Chemical Communications

Alternating co-synthesis of glycol nucleic acid (GNA) monomers with dicarboxylic acids via drying†

Ruiqin Yi, ORCID logo *a   Tony Z. Jia, ORCID logo ab   Markus Meringer, ORCID logo c   Luke K. Marshall,d   Chen Chen, ORCID logo a   Shawn Erin McGlynn, ORCID logo a   Albert C. Fahrenbachd  and  H. James Cleaves, II*ab  

* Corresponding authors

a Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo, Japan
E-mail: yiruiqin@elsi.jp, henderson.cleaves@gmail.com

b Blue Marble Space Institute of Science, Seattle, WA 98154, USA

c Earth Observation Center, German Aerospace Center, Oberpfaffenhofen – Wessling, Germany

d School of Chemistry, Australian Centre for Astrobiology and the UNSW RNA Institute, University of New South Wales, Sydney, NSW 2052, Australia

Abstract

We report the co-polymerization of glycol nucleic acid (GNA) monomers with unsubstituted and substituted dicarboxylic acid linkers under plausible early Earth aqueous dry-down conditions. Both linear and branched co-polymers are produced. Mechanistic aspects of the reaction and potential roles of these polymers in prebiotic chemistry are discussed.

Graphical abstract: Alternating co-synthesis of glycol nucleic acid (GNA) monomers with dicarboxylic acids via drying

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Article information

DOI
https://doi.org/10.1039/D2CC06818D
Article type
Communication
Submitted
14 Dec 2022
Accepted
26 Apr 2023
First published
29 Apr 2023

Chem. Commun., 2023,59, 6865-6868

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Alternating co-synthesis of glycol nucleic acid (GNA) monomers with dicarboxylic acids via drying

R. Yi, T. Z. Jia, M. Meringer, L. K. Marshall, C. Chen, S. E. McGlynn, A. C. Fahrenbach and H. J. Cleaves, Chem. Commun., 2023, 59, 6865 DOI: 10.1039/D2CC06818D

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