Issue 7, 2023

Miniature mass spectrometer-based point-of-care assay for measuring phosphatidylethanol in blood

Abstract

We demonstrate proof-of-concept for point-of-care assessment of long-term alcohol consumption by measuring phosphatidylethanol in blood/dried blood spots with nano-electrospray ionization and MS/MS using a miniature mass spectrometer. ‘Abstinence’, ‘moderate’, and ‘chronic’ consumption could be distinguished rapidly for both sample types, and quantitative performance was obtained with blood (LoQ-100 ng mL−1).

Graphical abstract: Miniature mass spectrometer-based point-of-care assay for measuring phosphatidylethanol in blood

Supplementary files

Article information

Article type
Communication
Submitted
17 Jan 2023
Accepted
20 Feb 2023
First published
28 Feb 2023

Analyst, 2023,148, 1430-1436

Miniature mass spectrometer-based point-of-care assay for measuring phosphatidylethanol in blood

S. Pandey, Y. Hu, P. L. Anderson, J. J. Kiser and R. G. Cooks, Analyst, 2023, 148, 1430 DOI: 10.1039/D3AN00098B

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