Issue 7, 2023

A NIR fluorescent probe for dual imaging of mitochondrial viscosity and FA in living cells and zebrafish

Abstract

Formaldehyde (FA) and viscosity play multiple roles in human health and diseases, and viscosity has great regional differences due to the diversity of subcellular organelles. However, it is challenging to achieve dual detection of viscosity and FA in subcellular organelles. Herein, we developed a near infrared (NIR) fluorescent probe FA-Cy, which can simultaneously monitor the viscosity and FA concentration of mitochondria in living cells. The probe could detect mitochondrial viscosity and exogenous and endogenous FA in living cells and zebrafish.

Graphical abstract: A NIR fluorescent probe for dual imaging of mitochondrial viscosity and FA in living cells and zebrafish

Supplementary files

Article information

Article type
Communication
Submitted
05 Oct 2022
Accepted
27 Feb 2023
First published
07 Mar 2023

Analyst, 2023,148, 1437-1441

A NIR fluorescent probe for dual imaging of mitochondrial viscosity and FA in living cells and zebrafish

F. Liang, W. Huang, L. Wu, Y. Wu, T. Zhang, X. He, Z. Wang, X. Yu, Y. Li and S. Qian, Analyst, 2023, 148, 1437 DOI: 10.1039/D2AN01628A

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