Access to cyclopentenones via copper-catalyzed 5-endo trifluoromethylcarbocyclization of ynones

Abstract

A Cu-catalyzed 5-endo-selective trifluoromethylcarbocyclization of ynones is developed for the concise synthesis of trifluoromethylated cyclopentenones. The pivotal roles of carbonyl groups are well illustrated by experiments and density functional theory calculations.