Palladium-catalyzed Heck cyclization/allylation with homoallyl alcohols via retro-allylation†
Abstract
A palladium-catalyzed reaction of aryl iodide-tethered alkenes with homoallyl alcohols is reported, providing a convenient and efficient approach to C(sp3)–allylation products. The cascade process involves intramolecular Heck/retro-allylation. This new approach has good functional group compatibility, broad substrate scope and high efficiency. This domino reaction further proved that homoallyl alcohols are convenient and efficient allylation sources.