Issue 15, 2022

Palladium-catalyzed Heck cyclization/allylation with homoallyl alcohols via retro-allylation

Abstract

A palladium-catalyzed reaction of aryl iodide-tethered alkenes with homoallyl alcohols is reported, providing a convenient and efficient approach to C(sp3)–allylation products. The cascade process involves intramolecular Heck/retro-allylation. This new approach has good functional group compatibility, broad substrate scope and high efficiency. This domino reaction further proved that homoallyl alcohols are convenient and efficient allylation sources.

Graphical abstract: Palladium-catalyzed Heck cyclization/allylation with homoallyl alcohols via retro-allylation

Supplementary files

Article information

Article type
Research Article
Submitted
22 Apr 2022
Accepted
18 Jun 2022
First published
21 Jun 2022

Org. Chem. Front., 2022,9, 4097-4103

Palladium-catalyzed Heck cyclization/allylation with homoallyl alcohols via retro-allylation

P. Zhou, X. Yang, X. Du, S. Zhao, H. Wang, X. Li, N. Liu, X. Tan, F. Ren and Y. Liang, Org. Chem. Front., 2022, 9, 4097 DOI: 10.1039/D2QO00655C

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