Issue 15, 2022

Synthesis of dihydropyrazoles enabled by Pd-catalyzed carboamination of alkenyl hydrazones with alkenyl and aryl halides

Abstract

Herein, a novel and highly efficient strategy for the synthesis of dihydropyrazoles via the Pd-catalyzed carboamination reaction of β,γ-unsaturated hydrazones with alkenyl and aryl halides is demonstrated. The present methodology provides a practical protocol for accessing various substituted dihydropyrazoles with good yields and good functional group tolerance.

Graphical abstract: Synthesis of dihydropyrazoles enabled by Pd-catalyzed carboamination of alkenyl hydrazones with alkenyl and aryl halides

Supplementary files

Article information

Article type
Research Article
Submitted
23 Apr 2022
Accepted
12 Jun 2022
First published
14 Jun 2022

Org. Chem. Front., 2022,9, 4104-4109

Synthesis of dihydropyrazoles enabled by Pd-catalyzed carboamination of alkenyl hydrazones with alkenyl and aryl halides

Y. Wang, S. Wu, L. Wang, J. Sun, C. Yan and Y. Han, Org. Chem. Front., 2022, 9, 4104 DOI: 10.1039/D2QO00653G

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