Rh(ii)-catalyzed synthesis of 5H-isochromeno[3,4-b]indolizines from 4-diazoisochroman-3-imines and pyridines

Abstract

A Rh(II)-catalyzed (3 + 2) annulation of pyridines with 4-diazoisochroman-3-imines leading to 5H-isochromeno[3,4-b]indolizines is presented. This methodology provides straightforward access to a wide variety of substituted 5H-isochromeno[3,4-b]indolizines with moderate to good yields (up to 84%) and complete regioselectivity.