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In this review, the incorporation of a cyclobutyl substituent in molecules, by transition metal-catalyzed cross-coupling, is described by only considering the formation of C–C bonds. Three main strategies are used to introduce a cyclobutyl substituent in molecules by involving either electrophilic or nucleophilic cyclobutane derivatives.

Graphical abstract: Incorporation of a cyclobutyl substituent in molecules by transition metal-catalyzed cross-coupling reactions

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