Issue 38, 2022

Directing group strategies in rhodium-catalyzed C–H amination

Abstract

Construction of a carbon–nitrogen bond is one of the most prevalent operations in nature and organic synthesis. The resulting amino compounds are privileged structural fragments in natural products, pharmaceutical drugs, and functional materials. With the rapid advancement of C–H bond activation, directing-group strategies in C–H amination catalyzed by rhodium have emerged. This reaction approach considerably enhances the step economy and atom economy of the reaction, and it complies with green chemistry and atom economy. The reactivity and selectivity of chelation-assisted rhodium-catalyzed C–H amination are discussed in relation to the types of aminating reagent, as well as the challenges and future development prospects in this field.

Graphical abstract: Directing group strategies in rhodium-catalyzed C–H amination

Article information

Article type
Review Article
Submitted
27 Jun 2022
Accepted
17 Aug 2022
First published
29 Aug 2022

Org. Biomol. Chem., 2022,20, 7554-7576

Directing group strategies in rhodium-catalyzed C–H amination

J. Ma, X. Zhou, J. Chen, J. Shi, H. Cheng, P. Guo and H. Ji, Org. Biomol. Chem., 2022, 20, 7554 DOI: 10.1039/D2OB01157C

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