Issue 23, 2022
From the journal:

Organic & Biomolecular Chemistry

Rapid sensing and imaging of methylglyoxal in living cells enabled by a near-infrared fluorescent probe†

Hai Xu,a   Xin-Rong Liu,a   Zheng-Hong Cai,a   Jianfeng Zheng, ORCID logo *a   Ya-Wen Wang*a  and  Yu Peng ORCID logo *a  

* Corresponding authors

a School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China
E-mail: jfzheng@swjtu.edu.cn, ywwang@swjtu.edu.cn, pengyu@swjtu.edu.cn

Abstract

A novel near-infrared fluorescent probe (SWJT-2) has been designed and synthesized for the detection of methylglyoxal (MGO). It showed a low detection limit (0.32 μM), high selectivity and the fastest detection (15 min) over various reactive carbonyl compounds in aqueous solution. SWJT-2 had been successfully applied to bioimaging in HeLa cells to detect exogenous and endogenous MGO.

Graphical abstract: Rapid sensing and imaging of methylglyoxal in living cells enabled by a near-infrared fluorescent probe

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Article information

DOI
https://doi.org/10.1039/D2OB00698G
Article type
Paper
Submitted
14 Apr 2022
Accepted
23 May 2022
First published
23 May 2022

Org. Biomol. Chem., 2022,20, 4782-4786

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Rapid sensing and imaging of methylglyoxal in living cells enabled by a near-infrared fluorescent probe

H. Xu, X. Liu, Z. Cai, J. Zheng, Y. Wang and Y. Peng, Org. Biomol. Chem., 2022, 20, 4782 DOI: 10.1039/D2OB00698G

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