Issue 20, 2022
From the journal:

Organic & Biomolecular Chemistry

Ni-catalysed deamidative fluorination of amides with electrophilic fluorinating reagents†

Feng-Wei Wu,‡a   Yang-Jie Mao, ORCID logo ‡a   Jun Pu,a   Huan-Le Li,a   Peng Ye,a   Zhen-Yuan Xu,a   Shao-Jie Lou ORCID logo *a  and  Dan-Qian Xu ORCID logo *a  

* Corresponding authors

a Catalytic Hydrogenation Research Center, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Zhejiang University of Technology, Hangzhou 310014, P. R. China
E-mail: loushaojie@zjut.edu.cn, chrc@zjut.edu.cn

Abstract

We describe here a Ni-catalysed deamidative fluorination of diverse amides with electrophilic fluorinating reagents. Different types of amides including aromatic amides and olefinic amides were well compatible, affording the corresponding acyl fluorides in good to excellent yields.

Graphical abstract: Ni-catalysed deamidative fluorination of amides with electrophilic fluorinating reagents

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Article information

DOI
https://doi.org/10.1039/D2OB00519K
Article type
Communication
Submitted
17 Mar 2022
Accepted
22 Apr 2022
First published
23 Apr 2022

Org. Biomol. Chem., 2022,20, 4091-4095

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Ni-catalysed deamidative fluorination of amides with electrophilic fluorinating reagents

F. Wu, Y. Mao, J. Pu, H. Li, P. Ye, Z. Xu, S. Lou and D. Xu, Org. Biomol. Chem., 2022, 20, 4091 DOI: 10.1039/D2OB00519K

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