Issue 23, 2022

Selective approach to N-substituted tertiary 2-pyridones

Abstract

The regio- and enantioselective amination of readily available vinyl cyclic carbonates with ambivalent 2-hydroxypyridines has been achieved using a Pd(0)/DACH-naphthyl catalyst system. The reaction proceeds under simple conditions, providing access to chiral N-substituted 2-pyridones that bear elusive tertiary carbon centers. A significant drawback previously related to making these products via transition metal-catalyzed allylic substitution procedures is overcome by this catalytic method.

Graphical abstract: Selective approach to N-substituted tertiary 2-pyridones

Supplementary files

Article information

Article type
Paper
Submitted
03 Mar 2022
Accepted
08 May 2022
First published
09 May 2022

New J. Chem., 2022,46, 11138-11142

Selective approach to N-substituted tertiary 2-pyridones

Y. Wang, Y. Xu, S. Khan, Z. Zhang and A. Khan, New J. Chem., 2022, 46, 11138 DOI: 10.1039/D2NJ01065H

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